Dr. Jeffrey WEBER (2002, 2003,
Dr. Jeffrey Weber is Adams Professor
of Medicine and Molecular Microbiology and Chief of
the Division of Medical Oncology at the Keck School
of Medicine of the University of Southern California.
He also is the Associate Director for Clinical Research
of the USC/Norris Comprehensive Cancer Center.
His interests lie in the field of cancer immunotherapy
and vaccine development. Dr. Weber is an experienced
clinical trialist and has been funded by the NCI for
the last decade to perform clinical immunotherapy trials
employing cytokines like Interleukin-12 and novel antibodies
against CTLA-4 to demonstrate their clinical utility
in combination with vaccines. Recently, anti-PD-1 antibody
has also been shown to augment the proliferation and
effector activity of tumor antigen-specific T cells.
Another interest is the prediction of outcome after
immunotherapy or vaccine treatment by analysis of genetic
polymorphisms in cytokine and immune regulatory genes.
He has also performed adoptive transfer studies using
dendritic cells in melanoma patients and has been among
the first to test vaccine strategies against human papillomaviruses
in patients with HPV-induced high grade cervical dysplasia.